Gene
EPIGENETIC MODIFICATIONS
1 variant(s) documented across Chronic Rhinosinusitis with Nasal Polyps
Variants
| Variant | Type | Frequency in disease | Significance | Also found in |
|---|---|---|---|---|
| DNA methylation changes at IL-13, IL-5, FOXP3 loci | unknown | Broadly observed in polyp tissue | Hypomethylation at type 2 cytokine loci and hypermethylation at regulatory T-cell loci (FOXP3) in polyp tissue. Suggests environmental epigenetic programming may be more important than germline variants. | — |
Clinical implications
DNA methylation changes at IL-13, IL-5, FOXP3 loci
May explain environmental risk factors. Epigenetic therapies are a future possibility.
Testing: methylation arrays, bisulfite sequencing
Related hypotheses
Epigenetic reprogramming by environmental exposures shapes disease susceptibility
30emerging·25 studies