Differential Diagnosis of Chronic Spontaneous Urticaria.

Key Findings

• ●Identifies key red flags distinguishing Schnitzler syndrome from chronic spontaneous urticaria: wheals lasting >24 hours, post-inflammatory hyperpigmentation, arthralgia, fever, elevated CRP
• ●Recommends serum immunofixation electrophoresis and genetic testing when red flags are present
• ●Discusses autoinflammatory, autoimmune, and malignant causes of chronic recurrent wheals
• ●From Charité Berlin group; highlights role of histology and laboratory work-up in differential diagnosis
• ●Case-based approach to DDx including Schnitzler syndrome and urticarial vasculitis

Referenced in (1 disease)