Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis

Key Findings

• ●POEMS clones identified via single-cell RNA-Seq with IGLV1-36, -40, -44, -47 sequences
• ●POEMS clones are CD19+, CD138+, MHC class II-low
• ●VEGF mRNA not upregulated in POEMS clones — VEGF not produced by clonal plasma cells
• ●IL-6 expression increased in POEMS clones, a known inducer of VEGF

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