CXCR4 in Waldenström's Macroglobulinemia: chances and challenges

Key Findings

• ●CXCR4 mutations affect up to 40% of WM patients with >40 different mutations described
• ●Mutations similar to germline WHIM syndrome mutations
• ●CXCR4 mutations lead to more aggressive clinical course and inferior BTK inhibitor response

Referenced in (1 disease)