A highly heterogeneous mutational pattern in POEMS syndrome

Chen J, Gao XM, Zhao H, et al.

Leukemia · 2021

Grade Bcohortn=42
DOI ↗PubMed ↗

Key Findings

  • ●170 somatic mutations in exonic regions from 10 patients via WES
  • ●Significantly mutated genes: LILRB1 (10%), HEATR9 (20%), FMNL2 (10%)
  • ●Driver genes including MYD88, NFKB2, STAT3, CUX1 identified
  • ●Heterogeneous genomic profiles distinct from multiple myeloma

Referenced in (1 disease)

POEMS Syndrome
ID: pmid-33262528DOI: 10.1038/s41375-020-01101-4PMID: 33262528