Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome

Key Findings

• ●Stereotypic amino acid changes in CDR1 and FR2 regions of IGLV1-40 and IGLV1-44
• ●Specific mutational patterns unique to POEMS syndrome
• ●Supports pathogenic role of restricted light chain gene usage

Referenced in (1 disease)