Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome

Key Findings

• ●Stereotypic amino acid changes in CDR1 and FR2 regions of IGLV1-40 and IGLV1-44
• ●Specific mutational patterns unique to POEMS syndrome
• ●Supports pathogenic role of restricted light chain gene usage

Referenced in (1 disease)

1. passsource metadataJun 1, 2026, 04:40 PMby pubmed-api

   Stored DOI was incorrect; corrected to the PubMed-registered DOI (verified to resolve to this article).

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