CXCR4 mutations affect presentation and outcomes in patients with WM: a systematic review

Key Findings

• ●Pooled CXCR4 mutation prevalence 31%; 34% in MYD88-mutated, 5% in MYD88-WT
• ●Associated with higher IgM levels and hyperviscosity risk
• ●Did not impact overall survival despite worse treatment response

Referenced in (1 disease)