What is the best first-line treatment for POEMS syndrome: autologous transplantation, melphalan and dexamethasone, or lenalidomide and dexamethasone?

Key Findings

• ●Compared ASCT (n=165), MDex (n=79), LDex (n=103) as first-line therapy
• ●ASCT achieved highest hematologic CR (49.7%)
• ●Neurological remission similar across groups (~93%)
• ●3-year PFS 80.5%, 3-year OS 90.8% overall

Referenced in (1 disease)