Genetic and transcriptional landscape of plasma cells in POEMS syndrome
Nagao Y, Mimura N, Takeda J, et al.
Leukemia · 2019
Grade Bcohortn=20
Key Findings
- ●308 somatic mutations in 285 genes via WES in 11 patients
- ●Recurrently mutated genes: KLHL6, LTB, EHD1, EML4, HEPHL1, HIPK1, PCDH10
- ●No myeloma driver genes (NRAS, KRAS, BRAF, TP53) detected
- ●Transcription profile specific to POEMS vs MGUS and myeloma
Referenced in (1 disease)
ID: pmid-30635632DOI: 10.1038/s41375-018-0348-xPMID: 30635632