Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.

Van Gorp H, Sber P, Van Hauwermeiren F, et al.

Proc Natl Acad Sci USA · 2016

Grade Abasic researchVerified
DOI ↗PubMed ↗

Key Findings

  • ●FMF mutations render pyrin activation independent of microtubules
  • ●Colchicine efficacy likely via leukocyte motility effects, not direct inflammasome block

Referenced in (1 disease)

Familial Mediterranean Fever

Validation history

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  1. passsource metadataJun 1, 2026, 04:40 PMby pubmed-api

    Identifier corrected: prior entry (pmid-27791120) had a wrong PMID/DOI pointing to an unrelated paper; re-resolved by title to this record via PubMed/Crossref.

    tools: pubmed.esummary, crossref.works

ID: pmid-27911804DOI: 10.1073/pnas.1613156113PMID: 27911804