Restrictive usage of monoclonal immunoglobulin lambda light chain germline in POEMS syndrome

Abe D, Nakaseko C, Takeuchi M, et al.

Blood · 2008

Grade Bcase seriesn=11
DOI ↗PubMed ↗

Key Findings

  • ●IGL V-region restricted to Vlambda1 subfamily in all 11 patients
  • ●IGLV1-44*01 (9/11) and IGLV1-40*01 (2/10) germlines identified
  • ●IGLJ3*02 gene used in all 11 rearrangements

Referenced in (1 disease)

POEMS Syndrome
ID: pmid-18497319DOI: 10.1182/blood-2008-01-114827PMID: 18497319