Neutrophils identified as predominant IL-1β source in SchS skin

Kambe et al. (2025) demonstrated that neutrophils are the main IL-1β-expressing cells in Schnitzler syndrome lesional skin and blood, using data from the SCan canakinumab study in Japanese patients. This provides mechanistic insight into why IL-1 blockade is so effective and positions neutrophil-targeted approaches as a research avenue.