incrementalMechanism
Thrombotic microangiopathy identified as driver of renal dysfunction in POEMS
POEMS Syndrome →Summary
Kidney biopsy series from Nakahama et al. (2020) established that thrombotic microangiopathy, rather than glomerulonephritis, is the predominant renal pathology in POEMS syndrome. VEGF-driven endothelial injury causes small vessel thrombosis and glomerular ischemia, explaining why renal function improves with VEGF-lowering treatments.
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ID: poems-syndrome-update-7Type: mechanismImpact: incremental