significantDiagnostic advance
International consensus diagnostic criteria updated with VEGF threshold
POEMS Syndrome →Summary
Dispenzieri (2019) proposed updated diagnostic criteria incorporating a plasma VEGF threshold of greater than 200 pg/mL as a major criterion, replacing the previous requirement for extravascular volume overload. The updated criteria improve sensitivity for early-stage POEMS while maintaining specificity against other plasma cell dyscrasias.
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ID: poems-syndrome-update-6Type: diagnostic_advanceImpact: significant