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FMF mutations confer resistance to Yersinia pestis — heterozygote advantage confirmed
Familial Mediterranean Fever →Summary
Park et al. (2020, Nat Immunol) demonstrated that FMF-associated pyrin mutations provide enhanced resistance to Yersinia pestis virulence factors. This explains the remarkably high carrier frequencies (1 in 3.5 to 1 in 5) in Mediterranean populations through positive evolutionary selection.
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ID: familial-mediterranean-fever-update-6Type: new_researchImpact: significant