Gene

DPP10

1 variant(s) documented across Schnitzler Syndrome

Variants

VariantTypeFrequency in diseaseSignificanceAlso found in
Autoantigen targetnot_foundIdentified as IgM targetDPP10 identified as a reactive autoantigen for the monoclonal IgM in some patients.—

Clinical implications

Autoantigen target

Potential link between the paraprotein and the inflammation. Needs further investigation.

Testing: immunoprecipitation, mass spectrometry

Related hypotheses

NLRP3 somatic mosaicism is the primary driver in a subset of patients

20
emerging·8 studies

Pyrin-inflammasome dysfunction (MEFV variants) contributes to pathogenesis

15
emerging·4 studies

Sources (1)

J4Qiao J et al. (2022) Schnitzler and Schnitzler-like syndromes reviewPubMed ↗