TNFAIP3 (A20)
NF-kB negative regulator (tumour suppressor)
- Expression
- Deleted in ~50% (6q deletion)
- Evidence level
- strong
Role in pathogenesis
TNFAIP3 encodes A20, a key negative regulator of NF-kB signaling. Loss through chromosome 6q21-23 deletion occurs in ~50% of WM patients, removing the braking mechanism on NF-kB and synergising with MYD88 L265P to drive constitutive pathway activation.