IRAK4
Myddosome kinase component
- Expression
- Constitutively activated
- Evidence level
- strong
Role in pathogenesis
IRAK4 is recruited to the Myddosome by mutated MYD88, along with IRAK1. Together they activate NF-kB through a pathway parallel to BTK. IRAK4 inhibitors are being explored as potential WM therapeutics.