HCK
SRC family kinase transactivated by mutated MYD88
- Expression
- Upregulated
- Evidence level
- moderate
Role in pathogenesis
Mutated MYD88 triggers HCK gene expression through PAX5-mediated signaling. HCK is activated via IL-6/IL-6R/gp130/JAK2/STAT3 signaling and triggers BTK, SYK, and ERK1/2 cascades, providing an additional layer of pro-survival signaling.