Serum Amyloid A (SAA)
Acute phase protein — amyloid precursor
- Expression
- Markedly elevated
- Evidence level
- established
Role in pathogenesis
SAA is produced by the liver in response to IL-6 and IL-1β. Persistent SAA elevation is the direct precursor to AA amyloidosis, the most serious TRAPS complication. SAA levels are a key monitoring biomarker and treatment target.