Serum Amyloid A (SAA)

Acute phase protein — amyloid precursor

Expression
Markedly elevated
Evidence level
established

Role in pathogenesis

SAA is produced by the liver in response to IL-6 and IL-1β. Persistent SAA elevation is the direct precursor to AA amyloidosis, the most serious TRAPS complication. SAA levels are a key monitoring biomarker and treatment target.

Sources (3)

DetailsDelaleu J et al. (2021) Tumour necrosis factor receptor-1 associated periodic syndrome (TRAPS)-related AA amyloidosis: a national case series and systematic review · Rheumatology (Oxford)DOI ↗
DetailsGattorno M et al. (2008) Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome · Arthritis RheumDOI ↗
DetailsGattorno M et al. (2024) Long-term efficacy and safety of canakinumab in patients with TRAPS: results from a phase III trial · Arthritis RheumatolDOI ↗