Colchicine
Microtubule inhibitor / anti-inflammatory
- Response rate
- 12.5% complete response
- Onset
- Weeks
- Route
- Oral 0.5–1mg daily
- Line
- Alternative
- IgM effect
- N/A
Evidence summary
AIDA Network real-life data shows colchicine monotherapy achieves complete response in only 12.5% of TRAPS patients, with partial response in 58% and no response in 29%. May be considered for patients with low-penetrance variants (INSAID Group B/C) and mild phenotypes where biologic therapy seems excessive.