DPP10
Genetic findings for DPP10 in Schnitzler Syndrome
Variants (1)
| Variant | Type | Frequency | Significance |
|---|---|---|---|
| Autoantigen target | not_found | Identified as IgM target | DPP10 identified as a reactive autoantigen for the monoclonal IgM in some patients. |
Clinical implications
Autoantigen target
Potential link between the paraprotein and the inflammation. Needs further investigation.
Related hypotheses
NLRP3 somatic mosaicism is the primary driver in a subset of patients
20emerging·8 studies
Pyrin-inflammasome dysfunction (MEFV variants) contributes to pathogenesis
15emerging·4 studies