KLHL6
Genetic findings for KLHL6 in POEMS Syndrome
Variants (1)
| Variant | Type | Frequency | Significance |
|---|---|---|---|
| Recurrently mutated (somatic) | somatic | Recurrent in WES cohorts | One of 7 recurrently mutated genes identified by Nagao et al. (2019) in POEMS plasma cells. KLHL6 is involved in B-cell receptor signaling and germinal center B-cell formation. Mutations may contribute to aberrant B-cell differentiation. |
Clinical implications
Recurrently mutated (somatic)
Research finding — no current clinical application.
Also found in: Diffuse large B-cell lymphoma (~5%)