Gasdermin D
Pyroptosis executor
- Expression
- Cleaved/activated
- Evidence level
- moderate
Role in pathogenesis
Gasdermin D is cleaved by caspase-1 during pyrin inflammasome activation. The N-terminal fragment forms pores in the plasma membrane, leading to pyroptosis (inflammatory cell death) and further IL-1beta/IL-18 release. Contributes to the amplification of FMF inflammatory attacks.