IL-6
Downstream cytokine
- Expression
- elevated
- Evidence level
- established
Role in pathogenesis
Induced by IL-1β signaling; drives hepatic acute phase response (CRP, SAA production). Secondary inflammatory mediator.
Sources (2)
J5Dinarello CA et al. (2012) Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases · Nat Rev Drug DiscovPubMed ↗
B6Moltrasio C et al. (2022) NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: from cryopyrin function to targeted therapies · Front Immunol