IL-6

Downstream cytokine

Expression
elevated
Evidence level
established

Role in pathogenesis

Induced by IL-1β signaling; drives hepatic acute phase response (CRP, SAA production). Secondary inflammatory mediator.

Sources (2)

DetailsDinarello CA et al. (2012) Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases · Nat Rev Drug DiscovDOI ↗
DetailsMoltrasio C et al. (2022) NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: from cryopyrin function to targeted therapies · Front Immunol