Caspase-1
Protease activating IL-1β and IL-18
- Expression
- elevated
- Evidence level
- established
Role in pathogenesis
Auto-activated by constitutive inflammasome assembly; cleaves pro-IL-1β and pro-IL-18 into active forms; also cleaves gasdermin D to initiate pyroptosis.
Sources (2)
B2Molina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production · Nat CommunPubMed ↗
B6Moltrasio C et al. (2022) NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: from cryopyrin function to targeted therapies · Front Immunol