MUC5AC
Gel-forming mucin
- Expression
- Upregulated
- Evidence level
- strong
Role in pathogenesis
IL-13 drives MUC5AC overexpression in goblet cells, causing the thick mucus secretion characteristic of CRSwNP. Contributes to sinus obstruction and mucus plug formation.
Sources (1)
P1Bachert C et al. (2020) EPOS 2020: endotype-based severity and treatment of CRSwNP · RhinologyDOI ↗