Aspirin desensitisation
COX-1 tolerance induction
- Response rate
- Effective in AERD
- Onset
- Weeks
- Route
- Oral escalating doses then daily maintenance
- Line
- AERD-specific
- IgM effect
- Slows polyp regrowth
Evidence summary
Specifically for AERD patients. Gradual aspirin dose escalation followed by daily maintenance (325–650mg) reduces polyp recurrence and need for revision surgery. Requires specialist supervision.
Sources (1)
T7Laidlaw TM et al. (2019) Aspirin desensitisation in AERD: outcomes and protocols · J Allergy Clin Immunol PractDOI ↗