Track disease research and
treatment progress
Research, biology, and treatments mapped from published papers. Track the progress as new findings come in.
How it works
Research, structured
Curated from research
Published papers, case reports, and trial data are systematically reviewed. Every claim traces back to graded evidence — not just answers, but competing hypotheses and open questions.
Structured and linked
Molecules, pathways, treatments, and genetic findings linked with evidence grades and source references. Machine-readable JSON-LD schema for every disease.
Updated continuously
New findings are integrated as they're published. Hypothesis trackers evolve. Evidence scores adjust. Subscribe for weekly research digests.
Diseases
Deep, evidence-linked references built from published research.
Adult-Onset Still's Disease
Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder characterized by the classic triad of quotidian (daily) spiking fevers, salmon-colored evanescent rash, and arthritis or arthralgia. First described in adults by Eric Bywaters in 1971 as the adult counterpart of systemic juvenile idiopathic arthritis, AOSD is driven by dysregulated innate immunity with excessive NLRP3 inflammasome activation and a cytokine storm involving IL-1, IL-18, and IL-6.
Chronic Rhinosinusitis with Nasal Polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the sinonasal mucosa characterised by bilateral polyp growth, persistent nasal obstruction, anosmia, and impaired quality of life. Driven predominantly by type 2 inflammation — with IL-4, IL-5, IL-13, and IgE as key mediators — CRSwNP affects 1–4% of the general population and 20–30% of all chronic rhinosinusitis patients.
Cryopyrin-Associated Periodic Syndromes
Cryopyrin-associated periodic syndromes (CAPS) are a spectrum of rare, inherited autoinflammatory disorders caused by gain-of-function mutations in the NLRP3 gene encoding cryopyrin. The spectrum encompasses three conditions of increasing severity: familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID/CINCA).
Familial Mediterranean Fever
Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease worldwide, caused by gain-of-function mutations in the MEFV gene encoding pyrin. It is characterized by recurrent self-limited episodes of fever and serositis (peritonitis, pleuritis, synovitis) lasting 1-3 days, predominantly affecting populations of Mediterranean descent.
Hypocomplementemic Urticarial Vasculitis Syndrome
Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare immune complex-mediated small vessel vasculitis characterised by chronic urticaria lasting >6 months, persistent hypocomplementemia (low C1q, C3, C4), and leukocytoclastic vasculitis on skin biopsy. First described by McDuffie et al.
POEMS Syndrome
POEMS syndrome is a rare paraneoplastic disorder caused by an underlying clonal plasma cell neoplasm. The acronym POEMS stands for Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, and Skin changes — though the syndrome encompasses far more features including sclerotic bone lesions, Castleman disease, papilledema, extravascular volume overload, and thrombocytosis.
Schnitzler Syndrome
Rare acquired autoinflammatory disorder characterised by chronic urticarial rash with monoclonal IgM gammopathy and systemic inflammation. First described in 1972 by Liliane Schnitzler, the syndrome involves dysregulated IL-1β signalling driving fever, bone pain, arthralgia, and elevated inflammatory markers.
Systemic Mastocytosis
Systemic mastocytosis is a clonal hematologic neoplasm characterized by abnormal proliferation and accumulation of neoplastic mast cells in one or more extracutaneous organs, primarily the bone marrow. Driven by activating KIT mutations — most commonly KIT D816V, found in >90% of adult cases — SM spans a clinical spectrum from indolent disease (ISM, ~75% of cases) with near-normal life expectancy to aggressive variants (ASM, SM-AHN, MCL) with poor prognosis.
TNF Receptor-Associated Periodic Syndrome
TNF Receptor-Associated Periodic Syndrome (TRAPS) is the most common autosomal dominant autoinflammatory disease, caused by heterozygous mutations in the TNFRSF1A gene encoding the type 1 TNF receptor (TNFR1). First described in 1982 as 'Familial Hibernian Fever' in an Irish family by Williamson et al.
Waldenström's Macroglobulinemia
Waldenström's macroglobulinemia is an indolent B-cell lymphoproliferative disorder characterised by bone marrow infiltration with clonal lymphoplasmacytic cells that secrete monoclonal IgM. First described by Jan Gösta Waldenström in 1944, the disease is defined molecularly by the MYD88 L265P somatic mutation, present in >90% of cases.