Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Van Gorp H, Sber P, Van Hauwermeiren F, et al.

Proc Natl Acad Sci USA · 2016

Grade Abasic research

Key Findings

  • FMF mutations render pyrin activation independent of microtubules
  • Colchicine efficacy likely via leukocyte motility effects, not direct inflammasome block

Referenced in (1 disease)

ID: pmid-27791120DOI: 10.1073/pnas.1613156113PMID: 27791120