Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

Growney JD, Clark JJ, Adelsperger J, et al.

Blood · 2005

Grade Bbasic research
DOI ↗

Key Findings

  • ●STAT5-PI3K cascade essential for KIT D816V-mediated MC growth and survival
  • ●Knockdown of Stat5 or Akt inhibits neoplastic KIT D816V+ MC growth

Referenced in (1 disease)

Systemic Mastocytosis
ID: doi-10-1182-blood-2004-12-4767DOI: 10.1182/blood-2004-12-4767