Plasmapheresis
Physical removal of IgM from circulation
- Response rate
- Immediate symptomatic relief
- Onset
- Hours
- Route
- IV (therapeutic plasma exchange)
- Line
- Adjunct
- IgM effect
- Acute reduction (temporary)
Evidence summary
Emergency treatment for symptomatic hyperviscosity syndrome. Rapidly reduces IgM and serum viscosity. Effect is temporary; definitive therapy must follow. Also used before rituximab in patients with high IgM to prevent IgM flare. Essential component of acute WM management.