Cromolyn sodium
Mast cell membrane stabilizer — reduces degranulation
- Response rate
- Moderate for GI symptoms
- Onset
- Weeks (1 month minimum trial)
- Route
- Oral 200mg four times daily (800mg/day)
- Line
- 2nd
- IgM effect
- N/A
Evidence summary
Mast cell stabilizer that interferes with calcium influx and reduces granule release. Mainly effective for GI symptoms (abdominal pain, diarrhea). Not systemically absorbed, so primarily acts locally in the GI tract. Should be tried for at least one month before judging efficacy.