Caspase-1

IL-1β converting enzyme

Expression
Constitutively active
Evidence level
moderate

Role in pathogenesis

Sits between NLRP3 and IL-1β. When NLRP3 assembles, caspase-1 cleaves pro-IL-1β into mature form.

Sources (1)

B2de Koning HD et al. (2015) IL-1β centrality via canakinumab trial · Arthritis Res TherDOI