Dapsone
Anti-neutrophilic; inhibits myeloperoxidase and neutrophil chemotaxis
- Response rate
- Effective for cutaneous symptoms in most cases
- Onset
- Days–weeks
- Route
- Oral 25-150 mg daily
- Line
- 2nd
- IgM effect
- Minimal complement effect
Evidence summary
Anti-neutrophilic agent effective for cutaneous manifestations of HUVS. Eiser et al. reported sustained remission in a patient resistant to cyclophosphamide and corticosteroids. May be the preferred agent for cutaneous-predominant disease. Requires G6PD testing before initiation.