C3
Central complement component
- Expression
- Depleted (consumed)
- Evidence level
- established
Role in pathogenesis
C3 is consumed during classical pathway activation. Its cleavage generates C3a (anaphylatoxin causing mast cell degranulation) and C3b (opsonin). C3 deposition in vessel walls is the most frequent direct immunofluorescence finding on skin biopsy.
Sources (3)
DetailsDavis MD et al. (1998) Clinicopathologic correlation of hypocomplementemic and normocomplementemic urticarial vasculitis · J Am Acad DermatolPubMed ↗