MIF
Genetic findings for MIF in Adult-Onset Still's Disease
Variants (1)
| Variant | Type | Frequency | Significance |
|---|---|---|---|
| Functional promoter polymorphisms | germline | Polymorphisms associated with disease susceptibility in some populations | Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that may contribute to AOSD pathogenesis through macrophage activation |
Clinical implications
Functional promoter polymorphisms
MIF polymorphisms may modulate disease susceptibility but are not yet clinically actionable
Also found in: Rheumatoid arthritis (Associated), Systemic lupus erythematosus (Associated)
Related hypotheses
Genetic susceptibility via HLA polymorphisms and autoinflammatory gene variants predisposes to AOSD
45emerging·12 studies